Eusebius of Caesarea
Catena Aurea · Lukasevangelium 17
In that day, he which shall he upon the housetop, and his stuff in the house, let him not come down to take it away: and he that is in the field, let him likewise not return back. Remember Lot’s wife. Whosoever shall seek to save his life shall lose it; and whosoever shall lose his life shall preserve it.
He hereby implies that a persecution will come from the son of perdition upon Christ’s faithful. By that day then He means the time previous to the end of the world, in which let not him who is flying return, nor care to lose his goods, lest he imitate Lot’s wife, who when she fled out of the city of Sodom, turning back, died, and became a pillar of salt.